Chapter 1, usually I and II
Basement, Cellar & Burning Basement
Build the first version of your run and learn its opening rooms before committing to a destination.
Preparation, checkpoints and exitsIsaac hub / Floors and modes
Repentance floor reference
Floor and chapter guides
Find your chapter, prepare for its checkpoint and check the exit before committing. Floor variants share a route position while changing layouts and boss pools.
The Womb transition deserves a check.
On the standard descent, ordinary hits become full-heart hits and regular Shops and Treasure Rooms stop naturally appearing. Exceptions depend on the damage source or item. Review Womb preparation.
Main chapters
Chapter 2, usually I and II
Caves, Catacombs & Flooded Caves
Develop damage, reach and resource access while the regular Treasure Rooms and Shops still support your build.
Preparation, checkpoints and exits
Chapter 3, usually I and II
Depths, Necropolis & Dank Depths
Mom and the next route decision make this chapter a checkpoint for both your build and your run goal.
Preparation, checkpoints and exits
Chapter 4, usually I and II
Womb, Utero & Scarred Womb
The standard run loses its regular shopping and item-room rhythm, while ordinary damage becomes more punishing.
Preparation, checkpoints and exitsAlternate path
Chained
OpenEarly alternate path, I and II
Downpour & Dross
The mirror checkpoint on floor II is the first major task on the standard Mother route.
Preparation, checkpoints and exits
Blocked
OpenMiddle alternate path, I and II
Mines & Ashpit
Floor II holds the second Knife Piece and a chase that should be planned before leaving.
Preparation, checkpoints and exits
Closed
OpenLate alternate path, I and II
Mausoleum & Gehenna
The standard Mother route spends health to enter and uses the completed knife after its Mom encounter.
Preparation, checkpoints and exits
Sealed
OpenAlternate-path finale, I and II
Corpse
The completed knife route ends in Corpse II with Mother, a different target from Mom.
Preparation, checkpoints and exitsLate and optional floors
Upper Chapter 5 route
Cathedral
The upward route leads to Isaac and, with The Polaroid, the standard Chest continuation.
Preparation, checkpoints and exits
Lower Chapter 5 route
Sheol
The downward branch leads to Satan and the standard Negative route to the Dark Room.
Preparation, checkpoints and exits
Upper Chapter 6 finale
Chest
The standard Polaroid route ends with ???, while the golden door offers a separate Mega Satan goal.
Preparation, checkpoints and exits
Lower Chapter 6 finale
Dark Room
The standard Negative route ends with The Lamb and can also support a prepared Mega Satan attempt.
Preparation, checkpoints and exits
Timed branch after Womb II
Blue Womb (???)
The timed branch supplies a preparation area before the Hush fight and a reliable unlocked route toward The Void.
Preparation, checkpoints and exits
Optional portal finale
The Void
An unusual late floor with several boss rooms, one of which contains Delirium.
Preparation, checkpoints and exitsStrange Door and Dad's Note route
Home & the Ascent
The run turns upward through the Ascent and finishes at Home with Dogma and The Beast sequence.
Preparation, checkpoints and exitsRepentance references, reviewed October 7, 2026. These guides describe standard routes with linked exceptions. Doors and boss portraits are extracted game art, not floor screenshots. Greed mode's arena route is covered separately. Repentance+ and mods can differ.