High Brow
Reward: Rune of Jera
Isaac hub
Challenge rewards
Pick a challenge for its reward.
Choose a useful challenge clear by the item, card, or rune it adds. Check the linked details before a run because availability and rules vary by version.
Curated list
9 challengesSelected rewards to prioritize, with direct source links.
Item connections
Collectible rewards link to their full effect pages. Runes and cards are identified by reward name here.
Search item databaseHead Trauma
Reward: Rune of Ehwaz
Darkness Falls
Reward: Rune of Dagaz
Solar System
Reward: Rune of Perthro
Demo Man
Reward: Chaos Card
When Life Gives You Lemons
Reward: A Card Against Humanity
Waka Waka
Reward: Death's Touch
The Host
Reward: Tech.5
The Family Man
Reward: Epic Fetus
| Challenge | Reward | Where to go next |
|---|---|---|
| #2High Brow | Rune of Jera | |
| #3Head Trauma | Rune of Ehwaz | |
| #4Darkness Falls | Rune of Dagaz | |
| #6Solar System | Rune of Perthro | |
| #9Demo Man | Chaos Card | |
| #12When Life Gives You Lemons | A Card Against Humanity | |
| #17Waka Waka | Death's Touch | |
| #18The Host | Tech.5 | |
| #19The Family Man | Epic Fetus |
These are selected rewards, not every challenge.
Browse curated unlocks