How you get here
Reached after the second standard chapter.
Prepare before the checkpoint
- Finish useful regular Shop and Treasure Room visits before leaving this chapter.
- If aiming for Home, arrange a way back from Mom's room before entering it.
- If aiming for Boss Rush, watch the standard 20-minute entry deadline and its special-effect exceptions.
Related item rules: route tools and exceptions mentioned in this guide. Read each effect before relying on it.
The Polaroid
The NegativeCheckpoint and exit
After Mom, choose the photograph your intended Chapter 6 route needs when those rewards are unlocked.
The ordinary descent continues to Womb. The unlocked Strange Door or alternate-path exits lead to different goals.
Random boss pools by variant
These counts come from the supplied boss-pool data. Pool membership and weight do not guarantee an encounter; fixed finales use route rules.
Depths: 8 listed entries
Necropolis: 7 listed entries
Dank Depths: 8 listed entries
Enemies worth recognizing
Learn the attack cue before entering a crowded room. These are selected preparation references for this floor family, rather than a complete spawn list.
BoilA stationary growth that shrinks under damage and swells again.
LeechA flying charger that commits when you share a row or column.
Kamikaze LeechA Leech that adds an explosion when it dies.
SuckerA slow pursuing fly with a four-way death burst.
Mom's HandA falling hand that can send Isaac back to the floor entrance.
Round WormA burrowing shooter that changes the origin of its next shot.