Blue Womb
- Do this
- Defeat Mom's Heart 10 times
- Reward
- Access to Hush
Isaac hub
Curated unlock database
Find the condition. Plan the run.
Search important route gates, characters, items, and challenge rewards. This selection highlights useful goals; item pages also show achievement-linked unlocks.
Goal planner
25 curated unlocksFilter character, progression, starting-item, and challenge goals below.
Full item references
370 item unlocksThe item database gives each linked collectible or trinket its own effect and unlock page.
Search all items25 of 25 curated unlocks
The Polaroid
- Do this
- Defeat Isaac five times
- Reward
- Chest route
The Negative
- Do this
- Defeat Satan five times
- Reward
- Dark Room route
A Secret Exit
- Do this
- Defeat Hush three times
- Reward
- Alternate path toward Mother
A Strange Door
- Do this
- Defeat Mother once
- Reward
- Home route on Depths II
Azazel
- Do this
- Take three Devil Room deals in one run
- Reward
- Playable Azazel
Lilith
- Do this
- Complete Greed Mode as Azazel
- Reward
- Playable Lilith
Bethany
- Do this
- Defeat Mom's Heart or It Lives as Lazarus on Hard without losing a life
- Reward
- Playable Bethany
Jacob & Esau
- Do this
- Defeat Mother
- Reward
- Playable Jacob & Esau
The Lost
- Do this
- Die in a Sacrifice Room while holding Missing Poster
- Reward
- Playable The Lost
Afterbirth and later method; Rebirth used a different sequence.
The Forgotten
- Do this
- Complete the Broken Shovel quest after defeating The Lamb
- Reward
- Playable The Forgotten
Keeper
- Do this
- Donate 1,000 coins to the Greed Donation Machine
- Reward
- Playable Keeper
Tainted characters
- Do this
- Open the hidden door in Home with Red Key, Cracked Key or Soul of Cain
- Reward
- The corresponding tainted character
Missing Poster
- Do this
- Defeat The Lamb as Isaac
- Reward
- Missing Poster can appear in later runs
Isaac's D6
- Do this
- Defeat Isaac as ??? (Blue Baby)
- Reward
- Isaac begins future runs with the D6
The Lost's Holy Mantle
- Do this
- Donate 879 coins to the Greed Donation Machine
- Reward
- The Lost starts with Holy Mantle
Rune of Jera
- Do this
- Complete challenge #2: High Brow
- Reward
- Rune of Jera
Rune of Ehwaz
- Do this
- Complete challenge #3: Head Trauma
- Reward
- Rune of Ehwaz
Rune of Dagaz
- Do this
- Complete challenge #4: Darkness Falls
- Reward
- Rune of Dagaz
Rune of Perthro
- Do this
- Complete challenge #6: Solar System
- Reward
- Rune of Perthro
Chaos Card
- Do this
- Complete challenge #9: Demo Man
- Reward
- Chaos Card
A Card Against Humanity
- Do this
- Complete challenge #12: When Life Gives You Lemons
- Reward
- A Card Against Humanity
Death's Touch
- Do this
- Complete challenge #17: Waka Waka
- Reward
- Death's Touch
Tech.5
- Do this
- Complete challenge #18: The Host
- Reward
- Tech.5
Epic Fetus
- Do this
- Complete challenge #19: The Family Man
- Reward
- Epic Fetus