Isaac hub
Progression
Which boss opens what?
Isaac's routes unlock in layers. Use these milestones to see the next gate and choose a run with a purpose.
Route overview
Work through the gates
Build Mom's Heart wins, then work toward Hush to open the alternate path. Defeating Mother opens the route to Home. Isaac and Satan wins unlock the photograph routes to Chest and Dark Room.
Gate 01
Mom's Heart
- Requirement
- Defeat Mom, then reach and defeat Mom's Heart in the Womb.
- What opens
- Repeat wins open more endings and later routes.
Gate 02
Blue Womb
- Requirement
- Defeat Mom's Heart 10 times.
- What opens
- Reach Hush by entering the timed Blue Womb entrance after the Womb boss.
Gate 03
The Polaroid and The Negative
- Requirement
- Defeat Isaac five times for The Polaroid and Satan five times for The Negative.
- What opens
- Take the matching photograph after Mom to reach Chest or Dark Room past Cathedral or Sheol.
Gate 04
Alternate path
- Requirement
- Defeat Hush three times.
- What opens
- Unlock A Secret Exit: Downpour, Mines, Mausoleum and the route to Mother.
Gate 05
Home and The Beast
- Requirement
- Defeat Mother once.
- What opens
- A Strange Door appears on Depths II, opening the route to Dad's Note, the Ascent and Home.