In-game pickup line
“Protect it”
Mechanics
What Isaac's Heart does
- Attacks against Isaac's body no longer hurt him; damage to the following heart familiar does.
- Charging by firing and then releasing sends out a burst of blood shots from the heart.
Achievement #129
How to unlock it
Defeat Isaac as The Lost.
Unlocking an item and finding it during a run are separate steps.
Explore more unlocksIn a run
Practical note
Watch the heart's position as you move, since a safe body position can still leave it in a projectile path.
Reference
Game data and sources
The item ID, quality and pool listings, icon, game-file tags, and short pickup line come from the extracted Repentance files. This effect explanation is an editorial summary checked against the references below. Repentance+ can differ.
