In-game pickup line
“What a cute little thing!”
Mechanics
What Blood Puppy does
- Blood Puppy seeks out and damages enemies; after 15 kills it becomes angry and can hurt Isaac too.
- At 40 kills it grows stronger again, while its later kills can produce Red Hearts. Damaging it enough calms it down.
Achievement #462
How to unlock it
Defeat Mother as Lilith.
Unlocking an item and finding it during a run are separate steps.
Explore more unlocksIn a run
Practical note
Track its kill count and give the angry puppy room to pass without touching Isaac.
Reference
Game data and sources
The item ID, quality and pool listings, icon, game-file tags, and short pickup line come from the extracted Repentance files. This effect explanation is an editorial summary checked against the references below. Repentance+ can differ.
