In-game pickup line
“The kiss of death”
Mechanics
What Serpent's Kiss does
- Isaac gains a chance to fire poisonous tears and also poisons enemies he touches.
- In Repentance, only enemies killed by the contact poison have a chance to drop a Black Heart.
Achievement #220
How to unlock it
Defeat Satan as Lilith.
Unlocking an item and finding it during a run are separate steps.
Explore more unlocksIn a run
Practical note
Use poisonous tears from a safe distance; chasing contact kills risks taking a hit.
Reference
Game data and sources
The item ID, quality and pool listings, icon, game-file tags, and short pickup line come from the extracted Repentance files. This effect explanation is an editorial summary checked against the references below. Repentance+ can differ.
