In-game pickup line
“In the beginning”
Mechanics
What Genesis does
- Genesis removes Isaac’s items and pickups, then sends him to a special bedroom with pickups and chests.
- For each removed item, choose one of three replacements from that item’s pool.
- Leaving the bedroom advances the run to the next floor.
Achievement #436
How to unlock it
Defeat Ultra Greedier as Jacob and Esau.
Unlocking an item and finding it during a run are separate steps.
Explore more unlocksIn a run
Practical note
Consider the current build before using it: the replacements come from the removed items’ pools, so specific synergies are not preserved.
Reference
Game data and sources
The item ID, quality and pool listings, icon, game-file tags, and short pickup line come from the extracted Repentance files. This effect explanation is an editorial summary checked against the references below. Repentance+ can differ.
