In-game pickup line
“What could it be?!”
Mechanics
What Buddy in a Box does
- The familiar takes the appearance of a random co-op baby and fires tears.
- Its tear effects are random and change when Isaac descends to a new floor.
Achievement #355
How to unlock it
Pick up five familiars in a single run.
Unlocking an item and finding it during a run are separate steps.
Explore more unlocksIn a run
Practical note
Check its current shots on each floor before planning around a particular effect.
Reference
Game data and sources
The item ID, quality and pool listings, icon, game-file tags, and short pickup line come from the extracted Repentance files. This effect explanation is an editorial summary checked against the references below. Repentance+ can differ.
